eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| wernicke-korsakoff syndrome | ||||
| Disease ID | 834 |
|---|---|
| Disease | wernicke-korsakoff syndrome |
| Definition | An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139) |
| Synonym | alcohol-induced encephalopathy korsakoff disease korsakoff psychoses korsakoff psychosis korsakoff syndrome korsakoff syndrome [disease/finding] korsakoff syndrome wernicke korsakoff's disease korsakoff's psychosis korsakoff's psychosis (disorder) korsakoff's psychosis, alcoholic korsakoff's syndrome korsakoffs psychosis korsakoffs syndrome korsakov psychosis korsakov psychosis (disorder) korsakov's psychosis korsakov's syndrome polyneuritic psychosis psychoses, korsakoff psychosis polyneuritica psychosis, korsakoff syndrome wernicke-korsakoff syndrome, korsakoff syndrome, wernicke-korsakoff syndromes, wernicke-korsakoff wernicke korsakoff syndrome wernicke-korsakoff psychosis wernicke-korsakoff syndromes wernicke-korsakov syndrome wernicke-korsakov syndrome (disorder) |
| OMIM | |
| DOID | |
| UMLS | C0349464 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:7) C0039841 | thiamine deficiency | 2 C0233795 | anterograde amnesia | 1 C0001973 | alcoholism | 1 C0033975 | psychotic disorder | 1 C0033975 | psychotic disorders | 1 C0497327 | dementia | 1 C0040188 | tic disorders | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:28) 186 | AGTR2 | 1.436 | DISEASES 551 | AVP | 1.605 | DISEASES 627 | BDNF | 1.351 | DISEASES 1103 | CHAT | 3.249 | DISEASES 2035 | EPB41 | 2.136 | DISEASES 27023 | FOXB1 | 3.994 | DISEASES 3363 | HTR7 | 1.76 | DISEASES 9851 | KIAA0753 | 3.741 | DISEASES 55554 | KLK15 | 2.819 | DISEASES 7044 | LEFTY2 | 2.896 | DISEASES 79104 | MEG8 | 2.053 | DISEASES 10763 | NES | 1.05 | DISEASES 4803 | NGF | 2.721 | DISEASES 4914 | NTRK1 | 1.207 | DISEASES 5091 | PC | 2.197 | DISEASES 139728 | PNCK | 2.424 | DISEASES 5455 | POU3F3 | 2.773 | DISEASES 5888 | RAD51 | 1.195 | DISEASES 146713 | RBFOX3 | 1.257 | DISEASES 862 | RUNX1T1 | 2.731 | DISEASES 12 | SERPINA3 | 1.231 | DISEASES 5271 | SERPINB8 | 2.857 | DISEASES 23583 | SMUG1 | 2.058 | DISEASES 284486 | THEM5 | 2.825 | DISEASES 7086 | TKT | 4.464 | DISEASES 8277 | TKTL1 | 2.214 | DISEASES 706 | TSPO | 1.67 | DISEASES 2547 | XRCC6 | 1.693 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 834 |
|---|---|
| Disease | wernicke-korsakoff syndrome |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:9) HP:0000666 | Horizontal nystagmus HP:0001251 | Ataxia HP:0001271 | Polyneuropathy HP:0001289 | Confusion HP:0001259 | Coma HP:0000709 | Psychosis HP:0000508 | Drooping upper eyelid HP:0002354 | Memory loss HP:0000602 | Ophthalmoplegia |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:4) HP:0002354 | Memory loss | 3 HP:0100033 | Tic disorder | 1 HP:0000708 | Behavioral problems | 1 HP:0000726 | Dementia | 1 |
| Disease ID | 834 |
|---|---|
| Disease | wernicke-korsakoff syndrome |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:6) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:9) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001271 | Polyneuropathy | MP:0020186 | altered susceptibility to bacterial infection | a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria |
| HP:0002354 | Memory impairment | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001289 | Confusion | MP:0020187 | altered susceptibility to prion infection | altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is |
| HP:0000508 | Ptosis | MP:0020321 | increased vascular endothelial cell apoptosis | increase in the timing or the number of vascular endothelial cells undergoing programmed cell death |
| HP:0000602 | Ophthalmoplegia | MP:0013785 | abnormal mammary gland bud morphology | any structural anomaly of the morphologically distinct bulb of epithelial cells formed once each mammary placode expands and invaginates into the underlying mesenchyme; in mouse embryos at E12.5, each epithelial bud with its contiguous mesenchyme is eleva |
| HP:0000709 | Psychosis | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001259 | Coma | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0001251 | Ataxia | MP:0020301 | short tongue | decreased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor |
| HP:0000666 | Horizontal nystagmus | MP:0014178 | increased brain apoptosis | increase in the number of cells of the brain undergoing programmed cell death |
| Disease ID | 834 |
|---|---|
| Disease | wernicke-korsakoff syndrome |
| Case | (Waiting for update.) |